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| Author: | Laxminarayan, R. Brown, G. M. |
| Title: | Economics of antibiotic resistance: a theory of optimal use |
| Journal: | Journal of Environmental Economics and Management
2001 : SEP, VOL. 42:2, p. 183-206 |
| Index terms: | Health economics Environmental economics Medicine Case studies |
| Language: | eng |
| Abstract: | The paper uses a framework based on an epidemiological model of infection in which antibiotic effectiveness is treated as a nonrenewable resource. In the model presented, bacterial resistance develops as a result of selective pressure on nonresistant strains due to antibiotic use. When two antibiotics are available, the optimal proportion and timing of their use depends precisely on the difference between the rates at which bacterial resistance to each antibiotic evolves and on the difference between the rates at which bacterial resistance to each antibiotic evolves and on the differences in their pharmaceutical costs. Standard numerical techniques are used to illustrate cases for which the analytical problem is intractable. |
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