search query: @instructor Joensuu, Pekka / total: 10
reference: 6 / 10
« previous | next »
Author:Gillard, Laurent
Title:Organocatalytic enantioselective Robinson annulation
Publication type:Final Project work
Publication year:2013
Pages:50 s. + liitt. 84      Language:   eng
Department/School:Kemian laitos
Main subject:Orgaaninen kemia   (Kem-4)
Supervisor:Koskinen, Ari
Instructor:Joensuu, Pekka
OEVS:
Electronic archive copy is available via Aalto Thesis Database.
Instructions

Reading digital theses in the closed network of the Aalto University Harald Herlin Learning Centre

In the closed network of Learning Centre you can read digital and digitized theses not available in the open network.

The Learning Centre contact details and opening hours: https://learningcentre.aalto.fi/en/harald-herlin-learning-centre/

You can read theses on the Learning Centre customer computers, which are available on all floors.

Logging on to the customer computers

  • Aalto University staff members log on to the customer computer using the Aalto username and password.
  • Other customers log on using a shared username and password.

Opening a thesis

  • On the desktop of the customer computers, you will find an icon titled:

    Aalto Thesis Database

  • Click on the icon to search for and open the thesis you are looking for from Aaltodoc database. You can find the thesis file by clicking the link on the OEV or OEVS field.

Reading the thesis

  • You can either print the thesis or read it on the customer computer screen.
  • You cannot save the thesis file on a flash drive or email it.
  • You cannot copy text or images from the file.
  • You cannot edit the file.

Printing the thesis

  • You can print the thesis for your personal study or research use.
  • Aalto University students and staff members may print black-and-white prints on the PrintingPoint devices when using the computer with personal Aalto username and password. Color printing is possible using the printer u90203-psc3, which is located near the customer service. Color printing is subject to a charge to Aalto University students and staff members.
  • Other customers can use the printer u90203-psc3. All printing is subject to a charge to non-University members.
Location:P1 Ark Aalto  2111   | Archive
Abstract (eng): The aim of the research was to find a catalytic and enantioselective way for the Robinson annulation reaction, our target molecule is the aspidospermine.

The use of amino-acid is really useful in enamine chemistry, because they are chiral amino-compounds and can be easily substituted.
Several primary and secondary amines were used as catalyst and a plethora of conditions were used to achieve this reaction.

It was observed that the relativities of primary and secondary amine were really different indicated their mechanisms are different.
No catalytic way to perform the reaction was found.
It was improved and now this path allows us to reach 88% of the desired product.

The catalytic way was developed with a sterically hindered catalyst.
However, the conditions to achieve this are not the best.
Attempts were performed to improve it, without any success.
The enantioselectivities reached by those catalysts was low.

The discovery of a possible interaction between the function of the catalyst and the enantioselectivity was established.
However only low enantiomer excess was developed.
The options are extensive, even if no very good e.e was achieved; there are still lots of opportunities in this field of research.
ED:2013-08-07
INSSI record number: 47035
+ add basket
« previous | next »
INSSI