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Author: | Ferreira, Tiago |
Title: | Catch the dream Wave, Propagation of Cortical Slow Oscillation to the Striatum in anaesthetised mice |
Publication type: | Master's thesis |
Publication year: | 2014 |
Pages: | 52 Language: eng |
Department/School: | Perustieteiden korkeakoulu |
Main subject: | Computational Systems Biology (IL3013) |
Supervisor: | Rousu, Juho ; Aurell, Erik |
Instructor: | Reig, Ramon |
Electronic version URL: | http://urn.fi/URN:NBN:fi:aalto-201411123010 |
OEVS: | Electronic archive copy is available via Aalto Thesis Database.
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Location: | P1 Ark Aalto 2013 | Archive |
Keywords: | Cortex Striatum anaesthesia slow oscillation spontaneous activity ketamine in vivo up states wavelet MUA high-gamma range MSNs |
Abstract (eng): | Under anaesthesia or in deep sleep, different parts of the brain have a distinctive slow oscillatory activity, characterised by states of high membrane potential and intensive spiking activity, the Up-states; followed by hyper-polarisation and quiescence, the Down-states. This activity has been previously described in vitro and in vivo in the cortex and the striatum, across several species. Here, we look into it, during anaesthesia, in the mouse brain. Using whole-cell patch-clamp recordings of cortical cells, it was possible to compare different signal processing methods used to extract the Up-and-Down states in extracellular recordings of the cortex. Our results show that the method based on the Multi-Unit Activity (> 200Hz) have better accuracy than High-Gamma Range (20 - 100Hz) or wavelet decomposition (< 2Hz band). After establishing the most robust method, this was used to compare the intracellular recordings of striatal cells to different parts of the cortex. The results obtained here support a functional connection between the dorsolateral striatal neurons and the ipsilateral barrel field. They also support a functional connection between dorsomedial striatal cells and the primary visual cortex. The analysis of delay between recordings allowed to establish temporal relationships between the contralateral barrel field, the ipsilateral barrel field, and the dorsolateral striatum; and between the ipsilateral barrel field, the ipsilateral primary visual field and the dorsomedial striatum. |
ED: | 2014-11-16 |
INSSI record number: 50036
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