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Author:Kiveliö, Anna-Sofia
Title:Superhydrophobic Coating for Reducing Unwanted Cell and Bacterial Adhesion in Medical Implants
Publication type:Master's thesis
Publication year:2009
Pages:83      Language:   eng
Department/School:Elektroniikan, tietoliikenteen ja automaation tiedekunta
Main subject:Elektroniikan valmistustekniikka   (S-113)
Supervisor:Paulasto-Kröckel, Mervi
Instructor:Turunen, Markus ; Wong, C. P. ; Boyan, Barbara
Electronic version URL: http://urn.fi/URN:NBN:fi:aalto-201203091391
OEVS:
Electronic archive copy is available via Aalto Thesis Database.
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Location:P1 Ark S80     | Archive
Keywords:superhydrophobic
sol-gel
anti-adhesion coating
cell adhesion
superhydrofobinen
sooli-geeli
likaantumaton pinnoite
soluadheesio
Abstract (eng): PURPOSE: The purpose of this master's thesis was to prepare and characterize superhydrophobic coatings and to evaluate cell and bacterial response to them, based on the hypothesis that superhydrophobic surfaces reduce or completely block bioadhesion.

MATERIALS AND METHODS: Glass and titanium disks were coated with a superhydrophobic coating, consisting of two different coatings (micro-and nanostructured coating and a low surface energy coating), as well as just these two coatings.
Modification of the coating with polydimethylsiloxane (PDMS) was also done in order to enhance itsmechanical properties for coating softer materials.
Cell response was tested by 1.
Culturing cells on the surfaces and evaluating their attachment by determining the number cells as well as examining cell morphology2.
MTT cell viability assay to evaluate coating toxicity.

RESULTS: Super hydrophobic surfaces displayed considerably reduced cell and bacterial adhesion compared to control samples, as well as the two individual coatings making up the super hydrophobic coating.
No evidence of coating toxicity of the original coating or the PDMS modification was observed.

CONCLUSION: Based on these preliminary tests, super hydrophobic coating can be used for coating medical implants in instances where cell and bacterial adhesion is not desired.
Abstract (fin): TYÖN TARKOITUS: Tämän diplomityön tarkoituksena oli valmistaa ja karakterisoida superhydrofobinen pinnoite sekä arvioida solujen ja bakteerien vastetta tälle pinnoitteelle, perustuen hypoteesiin, jonka mukaan superhydrofobinen pinnoite vähentää bioadheesiota tai estää sen täysin.

MATERIAALIT JA MENETELMÄT: Lasi- ja titaanikiekkoja päällystettiin superhydrofobisella pinnoitteella, sekä kahdella pinnoitteella (mikro- ja nanokonstruoitu pinnoite ja matalan pintaenergian pinnoite), joista superhydrofobinen pinnoite koostuu.
Alkuperäisestä pinnoitteesta valmistettiin myös polydimetyylisiloksaani (PDMS) polymeeriä sisältävä muunnos, minkä tarkoituksena oli parantaa pinnoitteen mekaanisia ominaisuuksia mahdollista pehmeiden materiaalien päällystämistä varten.
Solujen vastetta pinnalle testattiin 1. viljelemällä soluja pinnoilla ja tarkastelemalla kiinnittyneiden solujen määrää ja ulkomuotoa 2.
MTT testillä, jolla voidaan arvioida biomateriaalien solumyrkyllisyyttä.

TULOKSET: Superhydrofobinen pinnoite vähensi solujen ja bakteerien adheesiota huomattavasti, sekä kontrollinäytteisiin, että yksittäisiin pinnoitteisiin verrattuna.
Minkään pinnoitteista, PDMS muunnos mukaan lukien, ei havaittu olevan soluille myrkyllinen.
YHTEENVETO: Näiden alustavien tulosten perusteella voidaan sanoa, että tämä superhydrofobinen pinnoite soveltuu käytettäväksi sellaisten implanttien päällystämiseen, joihin solujen ja bakteerien adheesio ei ole toivottua.
ED:2010-12-01
INSSI record number: 41386
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