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Author:Pitkänen, Irina
Title:Nanofibrillated Cellulose Hydrogel for 3D Tissue Engineering
Nanokuituisen selluloosan käyttö 3D-kudosteknologiassa
Publication type:Master's thesis
Publication year:2014
Pages:ix + 52      Language:   eng
Department/School:Biotekniikan ja kemian tekniikan laitos
Main subject:Biologinen kemia ja biomateriaalit   (KE3005)
Supervisor:Seppälä, Jukka
Instructor:Partanen, Jouni
Electronic version URL: http://urn.fi/URN:NBN:fi:aalto-201405131785
OEVS:
Electronic archive copy is available via Aalto Thesis Database.
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Location:P1 Ark Aalto  1036   | Archive
Keywords:nanofibrillated cellulose
tissue engineering
additive manufacturing
Fab@Home
liver cells
nanokuituinen selluloosa
kudosteknologia
materiaalia lisäävä valmistus
maksasolut
Abstract (eng):The aim of this thesis was to find out if nanofibrillated cellulose based hydrogels are suitable for fabricating three dimensional tissue engineering constructs with additive manufacturing technologies.
Previous studies concerning the properties and applications of nanofibrillated cellulose were reviewed.
Additionally, the basic principles of additive manufacturing techniques were introduced, and the machine used in the experimental section was described in more detail.
Experiments were conducted to find out the rheological properties, optimal gel composition and printing parameters, and the biocompatibility of the hydrogels.
A three dimensional porous scaffold was printed with the optimal parameters.
Results showed that the nanofibrillated cellulose based hydrogels are shear thinning and highly viscous.
They are also suitable for three dimensional printing.
Initial cell cultures showed the gels to be biocompatible.
The results of this experiment show that nanofibrillated cellulose is potentially very suitable for tissue engineering.
Further experimentation should be conducted to explore the application possibilities of nanofibrillated cellulose hydrogels, and to improve print quality and resolution of the printing machine.
Abstract (fin):Tämän opinnäytetyön tavoitteena oli selvittää, voiko nanokuituista selluloosaa sisältäviä hydrogeelejä käyttää kolmiulotteisten keinokudosten valmistamiseen materiaalia lisäävillä valmistusmenetelmillä.
Kirjallisuuskatsauksessa on käyty läpi tutkimuksia, joissa selvitetään nanokuituisen selluloosan ominaisuuksia ja sovelluskohteita.
Lisäksi esitellään materiaalia lisäävien valmistusmenetelmien toimintaperiaatteet, ja tutustutaan tarkemmin kokeellisessa osuudessa käytettävään laitteeseen.
Kokeellisessa osiossa on tutkittu nanokuituista selluloosaa sisältävien geelien reologisia ominaisuuksia, sopivimpia geelikoostumuksia ja tulostusparametreja, sekä bioyhteensopivuutta.
Geelistä tulostettiin optimaalisilla tulostusparametreilla kolmiulotteinen, huokoinen kappale.
Kokeiden tulokset osoittivat, että nanokuitusta selluloosaa sisältävät hydrogeelit ovat leikkausohenevia, ja hyvin viskooseja.
Hydrogeelit soveltuivat myös kolmiulotteiseen tulostukseen.
Alustavat soluviljelykokeet näyttivät geelien olevan bioyhteensopivia.
Tulosten perusteella voidaan sanoa, että nanokuitusta selluloosaa sisältäviä hydrogeelejä voidaan hyödyntää kudosteknologisiin sovelluksiin.
Jatkotutkimuksia tulisi tehdä, jotta voitaisiin tarkemmmin selvittää sopivat sovelluskohteet, sekä parantaa tulostuksen laatua ja tulostuslaitteen resoluutiota.
ED:2014-05-18
INSSI record number: 49020
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