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Author:Hellman, Marika Johanna
Title:Enterovirusten aiheuttama solutuho
Cell death induced by Enteroviruses
Publication type:Master's thesis
Publication year:2012
Pages:xiv + 113 + [22]      Language:   fin
Department/School:Biotekniikan ja kemian tekniikan laitos
Main subject:Biokemia ja mikrobiologia   (Kem-30)
Supervisor:Nordström, Katrina
Instructor:Roivainen, Merja
OEVS:
Electronic archive copy is available via Aalto Thesis Database.
Instructions

Reading digital theses in the closed network of the Aalto University Harald Herlin Learning Centre

In the closed network of Learning Centre you can read digital and digitized theses not available in the open network.

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Location:P1 Ark Aalto  2108   | Archive
Keywords:enterovirus
cell death
diabetes
genetical properties
biological properties
enterovirus
solutuho
diabetes
geneettiset ominaisuudet
biologiset ominaisuudet
Abstract (eng): This master's thesis focuses primarily on the relationship between coxsackievirus and type I diabetes mellitus.
This study is a part of a larger research project which aims to clarify the proposed tendency of different coxsackieviruses to induce cell death in pancreatic cells.

Type I diabetes is a chronic disease in which the insulin producing pancreatic cells have gradually been destroyed by cell death.
Enteroviruses are believed to have the kinds of characteristics which increase the risk of type I diabetes.

The first step of the study was to select a few enterovirus strains that showed the most identical genetical relationships compared to a specific enterovirus which is considered to have diabetogenic features.
The second step was to study biological properties of these strains in pancreatic cells.
This study showed that coxsackie B -viruses' ability to grow in these cells is dependent on virus strain.

During the study, two coxsackie B -virus strains which showed major differences in biological properties were found.
These strains reproduced in pancreatic cells but showed no ability to induce cell death.
The reproduction was also slow compared to other enterovirus strains studied with a range of different methods.
The results of this master's thesis can be valuable for instance in the development of new approaches for prevention of virus induced damage in diabetes type I.
Abstract (fin): Tässä diplomityössä tavoitteena oli tuoda tietoa erityisesti coxsackieviruksien sekä tyypin I diabeteksen muodostumisen väliseen yhteyteen.
Tutkimus on osa kokonaisuutta, jossa selvitetään eri coxsackieviruksien taipumuksia aiheuttaa solutuhoa haiman soluissa.

Tyypin I diabetes on krooninen sairaus, jossa insuliinia tuottavat haiman solut ovat asteittain tuhoutuneet.
Enteroviruksilla uskotaan olevan tyypin I diabetekselle altistumista lisääviä ominaisuuksia.

Tässä tutkimuksessa tutkittiin valikoitujen enterovirusten geneettisiä molekulaarisuus suhteita ja näiden mahdollisia yhteyksiä diabetogeeniseen enteroviruskantaan.
Tulosten perusteella valikoitiin ne viruskannat, joiden biologisia ominaisuuksia selvitettiin haiman soluissa.
Työssä osoitettiin, että coxsackie B -virusten kyky kasvaa baimatiehytsoluissa on eri viruskannoille ominaista ja vaihtelee riippuen kannasta.

Tutkimuksissa löytyi kaksi biologisilta ominaisuuksiltaan erityisen poikkeavaa coxsackie B -viruskantaa, jotka eivät lisääntymisestä huolimatta aiheuttaneet solutuhoa haiman soluissa.
Näiden valittujen viruskantojen lisääntyminen oli haiman soluissa hidasta verrattuna muihin tutkittuihin kantoihin.
Tämä osoitettiin usein erilaisin menetelmin.
Saatuja tutkimustuloksia voidaan hyödyntää esimerkiksi taudin puhkeamista ennaltaehkäisevien hoitotoimenpiteiden kehityksessä.
ED:2012-04-23
INSSI record number: 44265
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